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The singing was improvisatory and intensified the functionality by repeating text and phrases, and punctuating with grunts, shouts, and moans. Timbres alternated concerning lyrical and percussive, shifted from superior to small pitches, and integrated bends, slides, melisma, and passing tones inside the melody. Instrumentalists imitated these vocal

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QT prolongation/torsade de pointes: Cases of QT prolongation and/or torsade de pointes happen to be noted with tramadol use. The formation of M1 metabolite depends on CYP2D6 action and will be motivated by inhibitory interactions, influencing the therapeutic response. Some individuals are "lousy metabolizers" with decreased CYP2D6 activity. CYP2D

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